ABSTRACT
The effect of prostaglandins (PGA1 and PGB2) on the replication of Mayaro virus was studied in Vero cells. PGA1 and PGB2 antiviral activity was found to be dose-dependent. However, while 10 µg/ml PGB2 inhibited virus yield by 60 percent, at the same dose PGA1 suppressed virus replication by more than 90 percent. SDS-PAGE analysis of [35S]-methionine-labelled proteins showed that PGA1 did not alter cellular protein synthesis. In infected cells, PGA1 slightly inhibited the synthesis of protein C, while drastically inhibiting the synthesis of glycoproteins E1 and E2
Subject(s)
Animals , Alphavirus/physiology , Prostaglandins A/pharmacology , Prostaglandins B/pharmacology , Vero Cells/drug effects , Virus Replication/drug effects , Alphavirus Infections/drug therapy , Alphavirus/drug effects , Alphavirus/growth & development , Glycoproteins/biosynthesis , Methionine/analysis , Prostaglandins A/metabolism , Prostaglandins A/therapeutic use , Prostaglandins B/metabolism , Prostaglandins B/therapeutic use , Protein C/biosynthesisABSTRACT
Las prostaglandinas (PG) E-2 y F-2 alfa tienen variadas acciones fisiologicas y farmacologicas. El presente trabajo es una revision bibliografica de estas acciones, profundizando en los efectos uterinos, farmacocinetica, las indicaciones, precauciones y contraindicaciones en su uso